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. 2016 Nov 9;15:187. doi: 10.1186/s12934-016-0591-7

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Production of PM100117 (1) and PM100118 (2) derivatives 3–9 in 2,6-DOH biosynthesis gene mutant strains. a UPLC analysis (254 nm) of metabolite production in S. caniferus GUA-06-05-006A wild-type and ΔgonCM, ΔgonD3, ΔgonE and ΔgonR1 deletion mutants. NR: peak non-related to PM100117/18. b Chemical structure of various PM100117/18 analogues