Table 3.
Effects of TNF-α inhibitor treatment on lipid profile
| Time | ||||||
|---|---|---|---|---|---|---|
| Baseline value before treatment | 0–6 months | 6–12 months | 12–18 months | 18–24 months | ||
| Total cholesterol (mg/dl) | Mean ± standard error | 180.85 ± 2.12 | 188.12 ± 2.35 | 183.80 ± 2.14 | 184.48 ± 2.08 | 184.88 ± 2.09 |
| p value | <0.0001 | NS | 0.030 | 0.015 | ||
| Multivariate modela
p value |
0.018 | NS | 0.041 | 0.018 | ||
| HDL (mg/dl) | Mean ± standard error | 51.8 ± 1.07 | 53.55 ± 1.21 | 51.06 ± 1.13 | 52.04 ± 1.18 | 52.05 ± 1.18 |
| p value | NS | NS | NS | NS | ||
| Multivariate modela
p value |
NS | NS | NS | NS | ||
| LDL (mg/dl) | Mean ± standard error | 108.70 ± 1.55 | 109.00 ± 1.92 | 108.42 ± 1.76 | 108.54 ± 1.75 | 108.67 ± 1.70 |
| p value | NS | NS | NS | NS | ||
| Multivariate modela
p value |
NS | NS | NS | NS | ||
| Triglycerides (mg/dl) | Mean ± standard error | 116.00 ± 3.55 | 132.02 ± 4.63 | 124.47 ± 3.95 | 128.72 ± 4.17 | 129.36 ± 4.32 |
| p value | <0.0001 | 0.005 | <0.0001 | <0.0001 | ||
| Multivariate modela
p value |
<0.0001 | 0.004 | <0.0001 | <0.0001 | ||
| Atherogenic index (LogTG/HDL) | Mean ± standard error | –0.032 ± 0.017 | –0.001 ± 0.02 | –0.01 ± 0.019 | 0.009 ± 0.018 | 0.004 ± 0.019 |
| p value | 0.005 | 0.043 | 0.001 | 0.003 | ||
| Multivariate modela
p value |
0.007 | 0.04 | 0.001 | 0.004 | ||
aAdjusted for hyperlipidemia, statin treatment, steroid treatment, rheumatic diseases (RA, AS, PsA), obesity, smoking, diabetes, hypertension, ischemic heart disease, gender, and age
TNF-α tumor necrosis factor alpha, HDL high-density lipoprotein, LDL low-density lipoprotein, TG, triglycerides, NS not significant, RA rheumatoid arthritis, AS ankylosing spondylitis, PsA psoriatic arthritis