Fig. 5.

GATA3 is linked to many enhancers in breast tumor tissues. a Shown is a circos plot of the enhancers having an active state positively linked to expression of GATA3. b Percentage of all tumor-specific enhancers (green), all tumor-specific enhancers linked to genes (red), and tumor-specific enhancers linked to GATA3, FOXA1, or ESR1 (blue) expression that overlap with TF ChIP-seq for GATA3, FOXA1, or ESR1. c Genome browser screen shots of an enhancer (containing probe cg04747693) having an active state in breast tumors, that is positively linked to expression of GATA3; the probe is located within a H3K27Ac and a GATA3 peak in MCF7 cells and in a hypomethylated region specifically found in non-basal breast cancer cells. d Shown is a scatterplot of the DNA methylation of the enhancer probe and GATA3 expression in normal and different subtypes of breast tumor tissues