Table 10.
Effect of FOM on antioxidant enzyme activities in acetaminophen induced hepatotoxicity in rats
| Treatment (mg/kg bw) | Catalase (U/mg protein) | SOD (U/mg protein) | GSH-Px (nM/min/mg protein) | GR (nM/min/mg protein) |
|---|---|---|---|---|
| Control (Saline) | 5.85 ± 0.13c | 4.23 ± 0.22d | 114.75 ± 0.97c | 127.53 ± 1.90d |
| AMP 750 | 2.44 ± 0.04a | 1.18 ± 0.25a | 69.82 ± 0.20a | 75.82 ± 1.65a |
| AMP + Sily 50 | 5.68 ± 0.21c | 4.32 ± 0.12d | 116.14 ± 0.31c | 125.31 ± 2.29c |
| AMP + FOM 200 | 3.95 ± 0.02b | 2.82 ± 0.10b | 81.52 ± 1.25b | 97.25 ± 1.85b |
| AMP + FOM 400 | 5.71 ± 0.15c | 3.78 ± 0.57c | 110.59 ± 2.18c | 116.84 ± 1.39c |
| FOM 400 | 5.89 ± 0.43c | 4.27 ± 0.49d | 118.72 ± 0.66c | 129.58 ± 1.75d |
Mean ± SEM (06). Means with different superscript letters (a-d) within the column indicate significant difference (p <0.05). AMP, acetaminophen; FOM, F. olivieri methanol extract