Table 11.
Effect of FOM on GSH, TBARS and DNA fragmentation in acetaminophen induced hepatotoxicity in rats
| Treatment mg/kg bw | GSH (μM/g tissue) | TBARS (nM/min/mg protein) | DNA fragmentation % | Total protein (μg/mg tissue) |
|---|---|---|---|---|
| Control (Saline) | 25.52 ± 0.63d | 1.85 ± 0.01d | 6.12 ± 0.01d | 4.90 ± 0.17d |
| AMP 750 | 10.96 ± 0.25a | 5.17 ± 0.18a | 32.18 ± 1.23a | 2.58 ± 0.52a |
| AMP + Sily 50 | 25.01 ± 0.64d | 1.71 ± 0.04d | 7.11 ± 0.16d | 3.96 ± 0.63b |
| AMP + FOM 200 | 17.23 ± 0.15b | 3.63 ± 0.53b | 22.85 ± 1.05b | 2.87 ± 0.52a |
| AMP + FOM 400 | 22.76 ± 0.14c | 2.51 ± 0.16c | 15.42 ± 1.32c | 3.64 ± 0.13c |
| FOM 400 | 25.14 ± 0.31d | 1.21 ± 0.50e | 8.31 ± 0.03d | 4.45 ± 0.22d |
Mean ± SEM (06). Means with different superscript letters (a-e) within the column indicate significant difference (p <0.05). AMP, acetaminophen; FOM, F. olivieri methanol extract