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. 2016 Nov 10;16:85. doi: 10.1186/s12935-016-0362-x

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Sensitivity of cell lines to cisplatin and 5-FU. a A613T and G462T mutations weaken the proliferation inhibition effect of 5-FU. Concentration of 5-FU was 0 to 50 μg/mL. b A613T and G462T mutations weaken the proliferation inhibition effect of cisplatin. Concentration of cisplatin was 0 to 8 μg/mL. WT: wild-type EC9706 cells; A613T: A613T mutation EC9706 cells; G462T: G462T mutation EC9706 cells; polβ^−/−: polβ null EC9706 cells (*P < 0.05)