Table 2.
Proportion of patients within “renal function” categories according to the different formulas
| Formula | MDRD4 | CKD-EPI | CG-BSA | P value | |||
|---|---|---|---|---|---|---|---|
| RF stage | Patients, n (%) | Events, n (%) | Patients, n (%) | Events, n (%) | Patients, n (%) | Events, n (%) | |
| Population-based | |||||||
| Stage 1: ≥ 90 | 521 (19.7) | 9 (1.7) | 425 (16.1) | 3 (0.7) | 429 (16.2) | 4 (0.9) | <0.001 |
| Stage 2: 60–89 | 1688 (63.8) | 26 (1.5) | 1701 (64.3) | 29 (1.7) | 1410 (53.3) | 17 (1.2) | <0.001 |
| Stage 3a: 45–59 | 353 (13.3) | 11 (3.1) | 395 (14.9) | 12 (3.0) | 602 (22.8) | 17 (2.8) | <0.001 |
| Stage 3b/4/5: < 45 | 83 (3.1) | 6 (7.2) | 123 (4.7) | 8 (6.5) | 203 (7.7) | 14 (6.9) | <0.001 |
| Cardiovascular risk | |||||||
| Stage 1: ≥ 90 | 1223 (5.9) | 27 (2.2) | 1165 (5.6) | 20 (1.7) | 1727 (8.3) | 28 (1.6) | <0.001 |
| Stage 2: 60–89 | 12,992 (62.2) | 388 (3.0) | 11,956 (57.2) | 335 (2.8) | 10,284 (49.2) | 253 (2.4) | <0.001 |
| Stage 3a: 45–59 | 5325 (25.5) | 242 (4.5) | 5845 (28.0) | 261 (4.5) | 6277 (30.0) | 293 (4.7) | <0.001 |
| Stage 3b/4/5: < 45 | 1355 (6.5) | 128 (9.4) | 1929 (9.2) | 169 (8.8) | 2607 (12.5) | 211 (8.1) | <0.001 |
| Heart failure | |||||||
| Stage 1: ≥ 90 | 229 (12.7) | 18 (7.8) | 165 (9.2) | 7 (4.2) | 179 (9.9) | 4 (2.2) | <0.001 |
| Stage 2: 60–89 | 738 (41.0) | 77 (10.4) | 685 (38.0) | 70 (10.2) | 533 (29.6) | 45 (8.4) | <0.001 |
| Stage 3a: 45–59 | 405 (22.5) | 71 (17.5) | 428 (23.8) | 63 (14.7) | 443 (24.6) | 62 (14.0) | <0.001 |
| Stage 3b/4/5: < 45 | 429 (23.8) | 117 (27.3) | 523 (29.0) | 143 (27.3) | 646 (35.9) | 172 (26.6) | <0.001 |
| Post-myocardial infarction | |||||||
| Stage 1: ≥ 90 | 4277 (15.3) | 405 (9.5) | 4210 (15.1) | 351 (8.3) | 4315 (15.8) | 337 (7.8) | <0.001 |
| Stage 2: 60–89 | 14,328 (51.4) | 1670 (11.7) | 13,400 (48.1) | 1515 (11.3) | 11,746 (43.1) | 1197 (10.2) | <0.001 |
| Stage 3a: 45–59 | 6261 (22.5) | 1247 (19.9) | 6453 (23.1) | 1228 (19.0) | 6746 (24.8) | 1219 (18.1) | <0.001 |
| Stage 3b: 30–45 | 2622 (9.4) | 793 (30.2) | 3174 (11.4) | 924 (29.1) | 3744 (13.7) | 1090 (29.1) | <0.001 |
| Stage 4/5: < 30 | 388 (1.5) | 162 (41.8) | 639 (2.4) | 259 (40.5) | 682 (2.6) | 280 (41.1) | <0.001 |
RF renal function, CG-BSA Cockcroft-Gault formula adjusted for body surface area, MDRD4 modification of diet in renal disease-4 formula, CKD-EPI Chronic Kidney Disease Epidemiology Collaboration equation
Events refer to cardiovascular mortality