Table 1.
The significantly enriched GO_BP terms (top 1) and KEGG pathways of up-regulated DEGs
| Term | Count | Gene lists | P-Value | Adjusted P-value |
|---|---|---|---|---|
| GO_BP: enrichment Score: 3.4367879252049858 | ||||
| GO_BP: 0048066 pigmentation during development | 7 | DCT, SOX10, TYRP1, TYR, MLPH, KIT, GPR143 | 3.63E-08 | 5.65E-05 |
| GO_BP: 0043473 pigmentation | 7 | DCT, SOX10, TYRP1, TYR, MLPH, KIT, GPR143 | 5.78E-06 | 0.009009 |
| GO_BP: 0042438 melanin biosynthetic process | 3 | DCT, TYRP1, TYR | 1.59E-03 | 2.449285 |
| GO_BP: 0006582 melanin metabolic process | 3 | DCT, TYRP1, TYR | 2.03E-03 | 3.123208 |
| GO_BP: 0046148 pigment biosynthetic process | 4 | DCT, TYRP1, TYR, GPR143 | 3.30E-03 | 5.019067 |
| GO_BP: 0042440 pigment metabolic process | 4 | DCT, TYRP1, TYR, GPR143 | 4.96E-03 | 7.448208 |
| GO_BP: 0030318 melanocyte differentiation | 3 | SOX10, TYRP1, MLPH | 5.02E-03 | 7.534839 |
| GO_BP: 0050931 pigment cell differentiation | 3 | SOX10, TYRP1, MLPH | 5.76E-03 | 8.604376 |
| KEGG | ||||
| hsa04080: Neuroactive ligand-receptor interaction | 6 | SSTR4, GPR156, KISS1R, OPRL1, NPBWR1, GRIN1 | 1.58E-02 | 13.80265 |
| hsa04916: Melanogenesis | 4 | DCT, TYRP1, TYR, KIT | 1.99E-02 | 17.11413 |
| hsa00350: Tyrosine metabolism | 3 | DCT, TYRP1, TYR | 2.73E-02 | 22.81886 |
Note: GO gene ontology, BP biological process, KEGG Kyoto encyclopedia of genes and genomes, DEGs differentially expressed genes. Count, the number of DEGs enriched in the corresponding term. The gene symbols were listed in accordance with the Gene database at NCBI (National Center for Biotechnology Information, http://www.ncbi.nlm.nih.gov/gene/?term)