Table 2.
The significantly enriched GO_BP terms (top 1) and KEGG pathways of down-regulated DEGs
| Term | Count | Gene lists | P-Value | Adjusted P-value |
|---|---|---|---|---|
| GO_BP: enrichment Score: 2.505066250961214 | ||||
| GO_BP: 0030097 hemopoiesis | 7 | GPR183, INHBA, PTPRC, PLEK, CD8A, IKZF1, FLT3 | 1.38E-04 | 0.218579 |
| GO_BP: 0048534 hemopoietic or lymphoid organ development | 7 | GPR183, INHBA, PTPRC, PLEK, CD8A, IKZF1, FLT3 | 2.34E-04 | 0.369612 |
| GO_BP: 0050865 regulation of cell activation | 6 | INHBA, PTPRC, PLEK, IKZF1, FLT3, IL1B | 3.05E-04 | 0.482267 |
| GO_BP: 0002520 immune system development | 7 | GPR183, INHBA, PTPRC, PLEK, CD8A, IKZF1, FLT3 | 3.22E-04 | 0.509185 |
| GO_BP: 0030098 lymphocyte differentiation | 5 | GPR183, PTPRC, CD8A, IKZF1, FLT3 | 4.05E-04 | 0.638643 |
| GO_BP: 0002521 leukocyte differentiation | 5 | GPR183, PTPRC, CD8A, IKZF1, FLT3 | 1.00E-03 | 1.572197 |
| GO_BP: 0045619 regulation of lymphocyte differentiation | 4 | INHBA, PTPRC, IKZF1, FLT3 | 1.27E-03 | 1.98708 |
| GO_BP: 0045577 regulation of B cell differentiation | 3 | INHBA, PTPRC, FLT3 | 1.32E-03 | 2.064808 |
| GO_BP: 0030217 T cell differentiation | 4 | PTPRC, CD8A, IKZF1, FLT3 | 1.39E-03 | 2.173407 |
| GO_BP: 0051249 regulation of lymphocyte activation | 5 | INHBA, PTPRC, IKZF1, FLT3, IL1B | 1.57E-03 | 2.458734 |
| KEGG pathways | ||||
| hsa04640: Hematopoietic cell lineage | 7 | CD8A, FLT3, CD1C, IL1B, CSF2RA, CD1E, IL1A | 1.18E-06 | 0.001103 |
| hsa04060: Cytokine-cytokine receptor interaction | 8 | INHBA, CCL22, FLT1, IL18RAP, FLT3, IL1B, CSF2RA, IL1A | 7.78E-05 | 0.072785 |
Note: GO gene ontology, BP biological process, KEGG Kyoto encyclopedia of genes and genomes, DEGs differentially expressed genes. Count, the number of DEGs enriched in the corresponding term. The gene symbols were listed in accordance with the Gene database at NCBI (National Center for Biotechnology Information, http://www.ncbi.nlm.nih.gov/gene/?term)