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Sampling areas and debridement summary at time 0 (white circle) and 6 months (black circle). Of the two periapical lesions (granulomas) pictured in the example radiograph, one features in the white circle. Where possible, sampling was made below the periapical lesion, into trabecular bone (black circle). A reference buccal supragingival biofilm sample from tooth 27 is not shown in the sampling scheme.
