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. Author manuscript; available in PMC: 2017 Sep 8.
Published in final edited form as: Cell. 2016 Sep 8;166(6):1471–1484.e18. doi: 10.1016/j.cell.2016.07.029

Figure 6. Selected IGHV1-2*02/IGKV3-20*01 IgGs cloned from the stepwise immunized mice displayed CD4bs-specific binding to multiple Env proteins.

Figure 6

ELISA endpoint binding titers of 27 IGHV1-2*02/IGKV3-20*01 paired IgGs cloned from the stepwise immunized mice 1540 (wk2), 1536 (wk6), 1539 (wk10) and 1538 (wk22) to various Env antigens and their CD4bs-KO mutants (Δ) were compared to the binding titers of VRC01 class antibodies and their germlines (gl). The number of VH1-2 AA mutations in each IgG is listed in the right-most column, and they are reversely correlated with the binding titers to C13 and 426c mutants (p<0.0001).