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. 2016 Oct 4;12(5):3308–3314. doi: 10.3892/etm.2016.3773

Figure 2.

Figure 2.

Effects of KXS on the TrkB/BDNF/ERK and TrkB/BDNF/PI3K signaling pathway in CMS rats. KXS (370 mg/kg) was administered daily for three weeks. Data are presented as the mean ± standard deviation, *P<0.05 vs. the control group; ##P<0.01 and #P<0.05 vs. the CMS group. CMS, chronic unpredictable mild stress; KXS, Kai-Xin-San; BDNF, brain-derived neurotrophic factor; Akt, protein kinase B; p, phospho; ERK, extracellular signal-regulated kinase; TrkB, tyrosine receptor kinase B; GSK3β, glycogen synthase kinase 3β; PI3K, phosphatidylinositol-3-kinase.