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. 2016 Sep 8;12(5):3153–3160. doi: 10.3892/ol.2016.5106

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Copyright: © Tian et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Effect of LP-15 RCC1 functional domain protein treatment on tumor cell morphology. (A) Control A549 cells exhibited regular morphology, with large nuclei and numerous mitochondria. (B) A549 cells treated with 200 µg Latcripin-15 RCC1 functional domain protein for 48 h exhibited apoptotic bodies (black arrow), chromatin condensation (white arrow), nuclear fragmentation and decreased numbers of mitochondria (magnification, ×1,000). RCC1, regulator of chromosome condensation; LP-15, Latcripin-15.