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. 2016 Aug 24;12(5):3278–3284. doi: 10.3892/ol.2016.5042

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Copyright: © Shen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — c(RGDfV) induces disruption of leukemia cell migration and adhesion in the 3D and 2D culture systems. (A) Fluorescence images of the adhesion between leukemia cells and osteoblasts following c(RGDfV) treatment in the 3D and 2D culture systems. Investigation of the effects of c(RGDfV) on the interaction between leukemia cells and osteoblasts indicated that c(RGDfV) inhibited adhesion in (B) 2D and (C) 3D culture systems; (D) migration was also inhibited in 3D cultures. (E) c(RGDfV) exhibited no effect on the level of OPN. (F) αvβ3 was expressed on the surface of the MV4–11 cells (37.8%). 3D, 3-dimensional; PBS, phosphate-buffered saline; OB, osteoblast; OPN, osteopontin. *P<0.05.