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. 2016 Aug 24;12(5):3278–3284. doi: 10.3892/ol.2016.5042

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Copyright: © Shen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — (A) c(RGDfV) affects the leukemia cell cycle. The stromal cells promoted the MV4–11 cells to stay at the stationary phase (P<0.05). c(RGDfV) exhibited little effect on the cell cycle of the MV4–11 cells without osteoblasts, while it promoted the leukemia cells to enter the cell cycle in the 3D and 2D culture systems. (B) c(RGDfV) decreased the G0/G1 phase of leukemia cells in the 3D and 2D culture systems. (C) c(RGDfV) increased the S phase of leukemia cells in the 3D and 2D culture systems. 1D, MV4–11 cells single culture; 2D, 2-dimensional; 3D, 3-dimensional; PBS, phosphate-buffered saline.*P<0.05.