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. 2016 Sep 7;12(5):3296–3304. doi: 10.3892/ol.2016.5101

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Copyright: © Dowling et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — IHC analysis of 14-3-3ε and FASN in primary and metastatic melanoma. (A) Representative photomicrograph showing decreased 14-3-3ε immunoreactivity in primary melanoma tumour tissue compared with metastatic melanoma tissue. (B) Representative photomicrograph showing increased 14-3-3ε immunoreactivity in metastatic melanoma tumour tissue compared with primary melanoma tissue. (C) Representative photomicrograph showing decreased 14-3-3ε immunoreactivity in primary melanoma tumour tissue compared with metastatic melanoma tissue. (D) Representative photomicrograph showing increased 14-3-3ε immunoreactivity in metastatic melanoma tumour tissue compared with primary melanoma tissue. (E) Positive control. Strong FASN immunoreactivity is observed in invasive ductal breast carcinoma. (F) Representative photomicrograph showing increased FASN immunoreactivity in metastatic melanoma tumour tissue compared with primary melanoma tissue. (G) Representative photomicrograph showing decreased FASN immunoreactivity in primary melanoma tumour tissue. (H) Representative photomicrograph showing increased FASN immunoreactivity in metastatic melanoma tumour tissues compared with primary melanoma tissue. Magnification, ×400. Scale bar=200 µm. FASN, fatty acid synthase.