Table II.
Type and distribution of KRAS/BRAF mutations in colorectal cancer patients.
| Sample | Tumor tissue | Normal tissue | Blood sample collected prior to surgery | Blood sample collected 5–7 days after surgery |
|---|---|---|---|---|
| 1 | p.Gln61Arg | wt | wt | wt |
| 2 | p.Gly12Asp | wt | wt | wt |
| 3 | p.Gly12Asp | wt | wt | wt |
| 4 | p.Gly12Arg | wt | wt | wt |
| 5 | p.Gly12Ser | wt | wt | wt |
| 6 | p.Gly12Asp | wt | wt | wt |
| 7 | p.Gly12Asp | wt | wt | wt |
| 8 | p.Gly12Asp | wt | p.Gly12Asp | wt |
| 9 | p.Gly12Val | wt | p.Gly12Val | wt |
| 10 | p.Gly12Val | wt | wt | wt |
| 11 | p.Val600Glu | wt | wt | wt |
| 12 | p.Val600Glu | wt | wt | wt |
| 13 | p.Gly13Asp | wt | wt | wt |
| 14 | p.Gln61His | wt | wt | p.Gln61His |
| 15 | p.Gly12Asp | wt | p.Gly12Asp | wt |
| 16 | p.Gly12Val | wt | p.Gly12Val | wt |
| 17 | p.Gly12Asp | wt | wt | wt |
| 18 | p.Gly12Asp | wt | wt | wt |
| 19 | p.Gly12Asp | wt | wt | ND |
| 20 | p.Gly12Cys | wt | p.Gly12Cys | p.Gly12Cys |
| 21 | p.Gly12Val | wt | p.Gly12Val | wt |
| 22 | p.Gly12Val | wt | p.Gly12Val | wt |
| 23 | p.Gly12Cys | wt | wt | wt |
| 24 | p.Val600Glu | wt | wt | wt |
| 25 | p.Gln61His | wt | wt | wt |
| 26 | p.Gln61His | wt | wt | wt |
| 27 | p.Gly12Ser | wt | wt | wt |
| 28 | p.Ala146x | wt | p.Ala146x | p.Ala146x |
| 29 | p.Val600Glu | wt | wt | wt |
| 30 | p.Gln61Leu | wt | wt | p.Gln61Leu |
| 31 | p.Gly12Asp | wt | p.Gly12Asp | p.Gly12Asp |
| 32 | p.Gln61His | wt | wt | wt |
| 33 | p.Gly12Alaq | wt | wt | wt |
| 34 | p.Gly12Asp | wt | p.Gly12Asp | wt |
| 35 | p.Ala146x | wt | p.Ala146x | p.Ala146x |
wt, wild-type; ND, not determined; x, the type of amino acid is not determined (it is either p.Ala146Thr, p.Ala146Pro or p.Ala146Val). KRAS, KRAS proto-oncogene, GTPase; BRAF, B-Raf proto-oncogene, serine/threonine kinase.