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. 2016 Sep 6;12(5):3351–3355. doi: 10.3892/ol.2016.5095

Figure 4.

Figure 4.

APRIL activates the mitogen-activated protein kinase ERK1/2 in A549 cells. (A) Extracts from A549 cells transfected with BCMA siRNA and TACI siRNA were subjected to western blotting and probed with antibodies against pERK1/2 and total ERK1/2. (B) Bar graphs represent the mean ± SEM (n=5; *P<0.05, one-way ANOVA). si, small interfering; NC, negative control; N.S., not significant; APRIL, a proliferation-inducing ligand; BCMA, B-cell maturation antigen; TACI, transmembrane activator and CAML interactor; ERK, extracellular signal regulated kinase; p, phosphorylated; WB, western blotting; ANOVA, analysis of variance; SEM, standard error of the mean.si, small interfering; NC, negative control; N.S., not significant; APRIL, a proliferation-inducing ligand; BCMA, B-cell maturation antigen; TACI, transmembrane activator and CAML interactor; ERK, extracellular signal-regulated kinase; p, phosphorylated; WB, western blotting; ANOVA, analysis of variance; SEM, standard error of the mean.