Figure 1.

(A) Histopathological features of a grade I spinal meningioma (classified according to the World Health Organization classification system) exhibiting whorl formations (arrows) and a psammoma body (star) (hematoxylin and eosin staining; scale bar, 200 µm). Sanger sequencing confirmed (B) wild-type c.3597G in germline analysis of the FAT2 gene, whereas (C) a c.3597G>C mutation was observed in the FAT2 gene of the spinal meningioma, resulting in p.Q1199H. (D) Schematic comparisons of FAT2 mutations between esophageal SCC and spinal meningioma. The arrows indicate the locations of mutations. The upward arrows in the cadherin repeats represent mutations of the FAT2 gene previously identified in esophageal SCC (15), whilst the downward arrow represents the mutation identified in the present study. EGF, epidermal growth factor; FAT2, FAT atypical cadherin 2; SCC, squamous cell carcinoma.