Figure 4.

Silencing of Notch4 enhances the sensitivity of pancreatic cancer cells to docetaxel treatment. MiaPaCa-2 and PANC-1 cells transfected with control siRNA or Notch4 siRNA were treated with various concentrations of docetaxel. Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Data are the mean ± standard deviation of ≥2 independent experiments (**P<0.01 vs. control siRNA; ##P<0.01 vs. Notch4 siRNA alone; $$P<0.01 vs. docetaxel alone). siRNA, small interfering RNA; A, absorbance.