Figure 6.

Dual inhibition of DDR1 and SFK decreased tumor growth of CNE2 cells in vivo. Nude mice were injected with CNE2 cells and divided into the following treatment groups: Normal saline, 7RH (8 mg/kg/day), dasatinib (10 mg/kg/day) and 7RH (8 mg/kg/day) ± dasatinib (10 mg/kg/day). The effect of 7RH and dasatinib treatment alone or combination on tumor development was assessed by measuring tumor size every 4 days until the end of the treatment (day 20). Solvent vs. dasatinib, P=0.05; solvent vs. 7RH, P=0.04; solvent vs. drug combination, P=0.03. P-values were calculated using the Student's t-test (two-sided). DDR1, discoidin domain receptor 1; SFK, SRC family kinase.