Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Sep 23;12(5):3723–3730. doi: 10.3892/ol.2016.5181

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Kuo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 3. — (A) Cisplatin could trigger an ER stress response in Mahlavu cells by activating the pro-apoptotic ATF4-ATF3-CHOP pathway. (B) The cisplatin-induced ER stress response concomitantly caused cellular GSH depletion in a concentration-dependent manner. (C) The cisplatin-induced cellular GSH depletion was demonstrated to be due to a strong inhibition of γ-GCS_h, an enzyme involved in the regulation of GSH biosynthesis. ER, endoplasmic reticulum; ATF, activating transcription factor; CHOP, C/emopamil binding protein homologous protein; CMF, 5-chloromethylfluorescein; GSH, glutathione; γ-GCS_h, γ-glutamylcysteine synthetase heavy chain.