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Proposed role of HIF-1α expression in VSMC in aortic elastin fiber formation. HIF-1α deficiency in VSMC suppresses tropoelastin and LOX expression in the vascular media, thereby diminishing mature cross-linked elastin fiber formation. VSMCHIF-1αKO mice exhibited augmented aortic aneurysm formation when infused with AngII + BAPN.
