Table 2.

Multi domain descriptive system for AD, and participants (NACC-UDS, n = 3009) by location

Domain severity level				State severity label	Number at baseline	Number at 12-month follow-up
Cognition	Behavior	Function	State name
1	1	1	111	Mild*	455	226
1	1	2	112	Mild*	581	444
1	1	3	113	Moderate	63	79
1	2	1	121	Mild*	101	44
1	2	2	122	Mild*	354	249
1	2	3	123	Moderate	56	82
1	3	1	131	Moderate	29	12
1	3	2	132	Moderate	97	84
1	3	3	133	Moderate	33	46
2	1	1	211	Moderate*	77	54
2	1	2	212	Moderate*	361	386
2	1	3	213	Moderate	159	245
2	2	1	221	Moderate*	20	14
2	2	2	222	Moderate*	191	207
2	2	3	223	Moderate	158	253
2	3	1	231	Moderate	5	5
2	3	2	232	Moderate	59	73
2	3	3	233	Severe	76	161
3	1	2	312	Severe	9	28
3	1	3	313	Severe	34	100
3	2	2	322	Severe	6	10
3	2	3	323	Severe	57	106
3	3	2	332	Severe	2	4
3	3	3	333	Severe	26	96
3	1	1	311	Severe	0	1
3	2	1	321	Severe	0	0
3	3	1	331	Severe	0	0

Columns 1–3: 1 refers to mild in cognition, no problem/mild in behavior, no problem in function; 2 refers to moderate in cognition, behavior and function; 3 refers to severe in cognition, behavior and function.

^*These eight health states are used to define a cohort of people with mild to moderate AD, i.e., 21% in state 111, 27% in state 112, and so on (see Table 5; showing 69.5% mild, 30.5% moderate AD). The defined cohort is used to demonstrate the application of the modeling framework in a health policy context.