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. Author manuscript; available in PMC: 2016 Nov 10.
Published in final edited form as: Cell Rep. 2016 Sep 27;17(1):69–85. doi: 10.1016/j.celrep.2016.08.073

Figure 2.

Figure 2

Nampt−cone/−cone mice exhibit cone-specific degeneration. (A) Cone-specific deletion of Nampt caused reduced intracellular NAMPT staining (red) in cone photoreceptors stained with cone-arrestin (green) and the nuclear DAPI stain (blue). (B) Representative fundus images from Nampt−cone/−cone mice demonstrated retinal pigment epithelial cell mottling (arrows) and optic nerve atrophy (arrowhead) consistent with mild retinal degeneration. (C–E) Nampt−cone/−cone mice also exhibited impaired retinal function on ERG (n=8–10 mice/group; 2-way mixed ANOVA with Bonferroni post-hoc test) and reduced photopic visual acuity (F; n=4 mice/group; Mann-Whitney U test). Graphs depict mean + S.E.M. (F) or mean ± S.E.M. (C–E) (* p < .05; ** p < .01; # p < .0001).