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. Author manuscript; available in PMC: 2016 Nov 10.
Published in final edited form as: Cell Rep. 2016 Sep 27;17(1):69–85. doi: 10.1016/j.celrep.2016.08.073

Figure 4.

Figure 4

NAD+ deficiency disrupts retinal energy homeostasis and can be rescued with exogenous NMN. (A–C) Wild-type mice (129S1/SvImJ) receiving intraperitoneal injections of 300 mg/kg NMN were more resilient against light exposure (n=8/group; 2-way mixed ANOVA with Bonferroni post-hoc test) compared to vehicle-treated mice. (D) Representative electron microscopy images of retinas from 4-week old Nampt−rod/−rod mice revealed mitochondria that are rounded, disorganized, and with loss of cristae compared to NamptF/F mice. (E) Nampt−rod/−rod retinas also exhibited significant disruption of numerous metabolic pathways on metabolite set enrichment analysis. Graphs depict mean ± S.E.M. (A–C) (* p < .05).