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. 2016 Sep 29;12(5):3926–3932. doi: 10.3892/ol.2016.5204

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Copyright: © Zhou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Expression levels of miR-298 and EZH2 mRNA in 100 EOC tissue specimens and 20 normal ovarian tissue specimens detected by reverse transcription-quantitative polymerase chain reaction assay and normalized to the levels of U6 small nuclear RNA B. (A) The expression level of miR-298 in EOC tissues was significantly lower than that in normal ovarian tissues (EOC vs. normal: 2.29±0.88 vs. 4.02±1.19, P<0.001). (B) The expression level of EZH2 mRNA in EOC tissues was significantly higher than that in normal ovarian tissues (EOC vs. normal: 3.73±1.07 vs. 1.65±0.58, P<0.001). (C) An inverse correlation exists between miR-298 and EZH2 mRNA expression levels (Spearman's correlation coefficient =−0.239, P=0.02). miR, microRNA; EZH2, enhancer of zeste 2; mRNA, messenger RNA; EOC, epithelial ovarian cancer.