Table IV.

Association between the mRNA expression of miR-196 and HoxB8 and the clinicopathological features of colorectal cancer.

Clinicopathological characteristics	n	Expression of miR-196 mRNA	Z-value	P-value	Expression of HoxB8 mRNA	Z-value	P-value
Gender			−0.968	0.333		−0.667	0.505
Male	19	1.551±1.100			1.767±1.237
Female	11	2.090±1.311			1.403±0.733
Age			−1.348	0.178		−1.597	0.110
>60 years	15	1.412±1.000			1.879±1.205
≤60 years	15	2.085±1.298			1.388±0.914
Tumor diameter, cm			−0.396	0.692		−0.352	0.725
>4	10	1.889±1.195			1.810±1.206
≤4	20	1.678±1.210			1.545±1.033
Macroscopic type of tumora			2.479b	0.290		2.516b	0.284
Ulcerative	18	1.658±1.183			1.782±1.175
Protrusive	8	1.489±1.151			1.658±1.036
Infiltrative	4	2.634±1.167			0.915±0.347
Tissue differentiationa			0.973b	0.615		0.410b	0.815
High	1	0.704±0.000			1.202±0.000
Moderate	28	1.792±1.214			1.674±1.107
Low	1	1.595±0.000			0.942±0.000
Tumor staging			−2.948	0.003		−1.276	0.202
I+II	10	0.847±0.349			1.854±1.071
III+IV	20	2.199±1.207			1.523±1.095
Depth of invasion			−0.610	0.542		−0.516	0.606
T1+T2	8	1.635±1.391			1.454±0.914
T3+T4	22	1.790±1.140			1.699±1.147
Tumor location			−0.125	0.901		−0.333	0.739
Rectum	16	1.696±1.133			1.609±0.882
Colon	14	1.809±1.290			1.661±1.305
Lymph node metastasis			−2.921	0.003		−1.482	0.138
Yes	18	2.245±1.153			1.504±1.132
No	12	1.005±0.816			1.827±1.012
Distant metastasis			−2.800	0.005		−0.726	0.468
Yes	3	4.146±0.758			1.220±0.840
No	27	1.482±0.892			1.679±1.107

^aKruskal Wallis H test

^bχ². Data are expressed as the mean ± standard deviation. miR, micro RNA; mRNA, messenger RNA; Hox, homeobox; miR, microRNA.