Figure 5.

Effect of curcumin on NF-κB-regulated gene expression. (A) Changes in fold expression of the (A) Bcl-extra large, (B) Bcl-2, (C) survivin, (D) c-Myc and (E) cyclin D1 genes. The data are presented as the fold-change in gene expression between the groups treated with chemotherapy alone and the groups treated with chemotherapy and curcumin.*P<0.05 vs. control. P, prednisone; 6MP, 6-mercaptopurine; D, dexamethasone; C, cyclophosphamide; L, l-asparaginase; V, vincristine; Da, daunorubicin; Do, doxorubicin; M, methotrexate; A, cytarabine; Ctrl, control; Bcl, B-cell lymphoma; xL, extra large; NF-κB, nuclear factor-kappa B.