Table I.
Effect of GL63 and CUR on the survival and development of nodules on DEN-induced hepatocarcinogenesis in rats.
| Group | Treatment | Survival, % | Tumor incidence, % | Average count of nodules/nodules bearing liver |
|---|---|---|---|---|
| 1 | Control | 100.0 (10/10) | – | – |
| 2 | GL63 alone | 100.0 (10/10) | – | – |
| 3 | CUR alone | 100.0 (10/10) | – | – |
| 4 | DEN alone | 52.0 (13/25)b | 100.0 (25/25)b | 17.53±1.29b |
| 5 | DEN + GL63 | 92.0 (23/25)d | 20.0 (5/25)d | 10.75±1.72d |
| 6 | DEN + CUR | 80.0 (20/25)c | 36.0 (9/25)d | 13.14±1.64d |
Results are expressed as the mean ± standard deviation.
a
P<0.05
b
P<0.01 vs. control group.
c
P<0.05
d
P<0.01 vs. DEN alone group. DEN, N-nitrosodiethylamine; CUR, curcumin; GL63, (1E,4E)-1,5-bis(2-bromophenyl)penta-1,4-dien-3-one.