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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Mol Cancer Ther. 2016 Jun 15;15(9):2187–2197. doi: 10.1158/1535-7163.MCT-15-0427

Figure 2.

Figure 2

Treatment with bevacizumab increases the expression of HIF1 alpha and TGF beta1 via POSTN. Immunofluorescent stains are shown for POSTN and the GSC markers nestin (A), TGF beta1 (B), and HIF1 alpha (C) in GSC272 mouse glioma xenografts with or without POSTN knockdown and/or treatment with bevacizumab. (A) Expression of POSTN (red) and of nestin (green) overlaps. (B) TGF beta1 (red) and POSTN (green) were expressed at different sites. (C) TGF beta1 (green) was expressed in F4/80-positive cells (red). (D) Immunofluorescent stains for POSTN (red) in relation to hypoxia marked by HIF1 alpha staining (green).