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. 2016 Oct 1;9(10):41–49.

TABLE 2.

Post-exposure prophylaxis protocols

GENERAL PROTOCOL
  • Immediately scrub out of surgery and wash injured area with soap and water

  • Contact either occupational health office or designated personnel, in order to obtain source testing and initiate post-exposure protocol

    –If injury occurs after hours, report to emergency room

HIV PROTOCOL
  • Rapid HIV test should be run on sample from source

  • If rapid HIV screen is positive or if source is untestable, HIV post-exposure prophylaxis (three drug regimen for four weeks) should be initiated

    –If HIV PEP is initiated, renal and hepatic function should be assessed at baseline and at 2 weeks

  • The injured health care worker should be tested for HIV at baseline, 6 weeks, 12 weeks, and 6 months post-injury

    –If combination HIV p24 antigen-HIV Antibody tests are utilized, the injured health care worker only has to be tested at baseline, 6 weeks, and at 4 months

  • Until HIV transmission has been ruled out, the injured health care worker should be advised to avoid pregnancy, breastfeeding, blood or tissue donation

HCV PROTOCOL
  • Anti-HCV Ab screening should be run on sample from source

  • The injured health care worker should have a baseline anti-HCV Ab and ALT measured followed by a repeat anti-HCV Ab and ALT in 4–6 months or a HCV RNA in 4–6 weeks

  • In the event of an HCV transmission, the health care worker should be referred to hepatology and infectious disease for treatment options

  • Sexual and lactation practices should not be altered in the case of exposure to HCV

HBV PROTOCOL
  • All health care workers should receive the 3-dose HBV vaccination series, followed by post-vaccination serology to confirm a positive response (defined as levels of anti-HBs >/=10 mIU/mL)

    –If the health care worker is vaccinated and has a confirmed positive response, then no further action is required with respect to HBV transmission

    If the health care worker does not have proof of a positive response or has not been vaccinated, he/she will receive a combination of the HBV vaccine series along with HBV immune globulin

  • Sexual and lactation practices should not be altered in the case of exposure to HBV