. 2016 Nov 10;11(11):e0166449. doi: 10.1371/journal.pone.0166449

Table 4. Overview of studies describing pancreatic cancer survival in relationship with a low socioeconomic status.

Author	Year of public-cation	Number of patients	Tumor	% resectionadeno-carcinoma	Influence of low SES
Author	Year of public-cation	Number of patients	Tumor	% resectionadeno-carcinoma	Survival (MV)	Surgery	Chemo-therapy	Radio-Therapy	Other
Blot[23]	1978	United States survey	PaC	^-	None	^-	^-	^-	Higher pancreatic mortality in urban residents
Janes[24]	1996	16,942	PaC	8.8	^-	^↓	^↓	^↓	More resections and lower postoperative mortality if treated in high volume center or in teaching hospital
Krzyzanowska[25]	2003	1,696	LA-PaC	^-	^-	^-	^↓	^↓	More cancer directed therapy if treated in teaching hospital
Lim[21]	2003	396	PaC	Only patients who underwent resection	^↓	^↓	^↓	^↓	Better survival if surgery in teaching hospital
Van Oost[26]	2006	1,130	PaC	11	^-	^-	^-	^-	Low SES: less referred to university hospital
Cress[14]	2006	10,612	PaC	15.8	^↓(UV)	^↓	^-	^-
Zell[27]	2007	24,735	70.1% PaC	11.8	^↓ (UV)	^↓	^↓	^↓
Le[28]	2008	15,296	66.6% PaC 0.3% IPMN	12	None^*	^↓	^↓	^↓
Kuhn[22]	2009	117	PaC	Only patients who underwent resection	None	^-	^-	^-
Cheung[2]	2010	16,104	PaC	18.8^†	^↓	^↓	^↓	^↓	Low SES: younger at diagnosis
Seyedin[29]	2012	5,908	PaC	No data	^-	^↓	^-	^-
Cheung[30]	2013	58,747	PaC	16.2	^-	^↓	^-	^-
Bernards[13]	2014	1,494	PaC^**	^-	^-	^-	^↓	^-
Enewold[31]	2015	977	PaC	22.1	None	None	^-	^-	Low SES: more frequently associated with no treatment
Wolfson[32]	2015	2,317	PaC	^-	^-	^-	^-	^-	Low SES: less patients treated in NCICCC facility^∫
Markossian[33]	2015	245	PaC	29	^↓	^-	^-	^-
Shapiro[5]	2015	17,530	PaC	45.4	^-	^↓	^-	^-	Lower SES: worse stage at presentation
Present Series		34,757	PaC	14.9	^↓	^↓	^↓	^-

Abbreviations: PaC: pancreatic adenocarcinoma; LA-PaC: locally advanced pancreatic cancer; IPMN: intraductal papillary mucinous neoplasms;

^-: no data;

^↓: decreased;

MV: multivariable analysis;

UV: univariable analysis;

*: only studied for IPMN tumors;

^†: patients treated surgically (not only resection);

NCICCC: National Cancer Institute Comprehensive Cancer Center;

^∫: patients treated in a NCICCC had better survival and were presented with lower stage of disease;

**: only patients with metastatic disease.