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. Author manuscript; available in PMC: 2017 Sep 16.
Published in final edited form as: ACS Chem Biol. 2016 Jul 29;11(9):2588–2595. doi: 10.1021/acschembio.6b00602

Figure 3.

Figure 3

Sequence and predicted structure of peptides originating from the rat pancreatic prohormone. (a) Sequence of rat pancreatic prohormone (UNIPROT ID: P06303, PAHO_RAT); the dibasic sites are underlined. (b) Observed peptide products resulting from processing of the pancreatic prohormone (filled color boxes). (c) Ab initio-calculated structure of PP; the dibasic site is outlined in magenta. (d) Molecular modeling shows that the N- and C-terminal products (sea green and sky blue, respectively) resulting from cleavage at the dibasic site retain the α-helix folding of the parent peptide.