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Effect of Pgp deletion on SREBP-2 and LXR activation in the jejunum. (A) Relative to wild type mice, Pgp knockout mice have reduced expression of genes under the transcriptional control of SREBP-2 after administration of the NFNC diet. (B) Wild type and Pgp knockout mice do not show alterations to the expression of genes under transcriptional control of LXR. Mean values shown ± SD, n=9–10. *p<0.05 vs. WT by unpaired t-test
