Table 1.
Effect of diet and deletion of P-glycoprotein on serum cholesterol parameters after nine weeks on the test diets.
| Genotype | Diet | n | Serum cholesterol content (mg/dL)
|
|||||
|---|---|---|---|---|---|---|---|---|
| Total cholesterol | Unesterified cholesterol | |||||||
| mean | ± | SD | mean | ± | SD | |||
| Wild Type | NFNC | 8 | 164.0 | ± | 48.0 | 44.2 | ± | 44.2 |
| HFNC | 8 | 150.1 | ± | 30.6 | 59.0 | ± | 59.0 | |
| NFHC | 7 | 188.4 | ± | 28.0 | 53.9 | ± | 53.9 | |
| HFHC | 7 | #216.3 | ± | 34.8 | #79.5 | ± | 79.5 | |
|
| ||||||||
| Pgp knockout | NFNC | 8 | 144.8 | ± | 33.9 | 48.8 | ± | 21.8 |
| HFNC | 8 | 165.5 | ± | 33.0 | 50.4 | ± | 22.2 | |
| NFHC | 8 | 177.4 | ± | 42.9 | 52.8 | ± | 9.1 | |
| HFHC | 8 | #209.3 | ± | 38.5 | #79.9 | ± | 21.9 | |
Serum was collected and analyzed for total and unesterified cholesterol content using cholesterol oxidase-based assays.
#
p<0.05 relative to the NFNC diet by two-way ANOVA with Tukey post-hoc tests; n=7–8.