Table 2.

Age and FI Before and After Onset of MOF at Year 1 and Year 2 Post-baseline

Factors	Year 1 post-baseline			Year 2 post-baseline
	With MOF (n = 60)	Without MOF (n = 3699)	p Value	With MOF (n = 48)	Without MOF (n = 3457)	p Value
Before MOFa
Age (years), mean (SD)	71.9 (9.53)	69.2 (8.74)	0.019	70.3 (8.80)	69.8 (8.59)	0.65
FI, mean (SD)	0.28 (0.15)	0.24 (0.14)	0.008	0.34 (0.18)	0.28 (0.16)	0.003
After MOFb
Age (years), mean (SD)	74.0 (9.50)	70.9 (8.84)	0.017	72.4 (8.78)	71.8 (8.58)	0.63
FI, mean (SD)	0.37 (0.19)	0.30 (0.17)	0.004	0.42 (0.21)	0.33 (0.18)	<0.001
Change before and after the onset of MOFc
FI, mean (SD)	0.085 (0.086)	0.067 (0.077)	0.036	0.080 (0.11)	0.052 (0.097)	0.042

FI = frailty index; MOF = major osteoporotic fracture; SD = standard deviation.

^aFor year 1, information before MOF was collected from baseline; for year 2, information before MOF was collected from year 1.

^bFor year 1, information after MOF was collected from year 2; for year 2, information after MOF was collected from year 3.

^cThe change of FI for year 1 is denoted as FI_{(year 2 – baseline)}; the change of FI for year 2 is denoted as FI_{(year 3 – year 1)}.