Table 4.

Results from sensitivity analyses using accelerated failure time models for major osteoporotic fracture and hip fracture.

Model	Major osteoporotic fracturea (n = 149)		Hip fracture (n = 18)
	HR (95% CI)e	p-Value	HR (95% CI)e	p-Value
Models with per-0.01 increment
FRAX	1.03 (1.02–1.05)	<0.001	1.05 (1.02–1.09)	0.003
FIb	1.03 (1.01–1.04)	<0.001	1.03 (1.00–1.08)	0.049
Models with categorized groups
FRAXc
Medium-risk			N/Af	N/Af
<365 days	1.38 (0.80–2.40)	0.25
365–550 days	1.45 (0.80–2.64)	0.23
>550 days	1.76 (1.03–3.02)	0.039
High-risk			4.05 (1.12–14.73)	0.034
<365 days	1.93 (0.97–3.85)	0.062
365–550 days	2.02 (1.10–3.72)	0.024
>550 days	2.45 (1.46–4.14)	0.001
FIb,d
Medium-risk	1.23 (0.82–1.85)	0.30	N/Af	N/Af
High-risk	2.04 (1.36–3.07)	0.001	2.09 (0.72–6.05)	0.17

HR: hazard ratio; CI: confidence interval; FRAX: fracture risk assessment tool; FI: frailty index.

^aHip, upper arm or shoulder, spine, or wrist.

^bAdjusted for age.

^cLow-risk group taken as reference group; the cut-points were 10% and 20% for major osteoporotic fracture, while the cut-point was 3% for hip fracture; comparisons of high-risk versus low-risk and medium-risk versus low-risk group were within the same follow-up duration strata.

^dLow-risk group taken as reference group; the cut-points were 0.20 and 0.35 for major osteoporotic fracture, while the cut-point was 0.22 for hip fracture; comparisons of high-risk versus low-risk and medium-risk versus low-risk group were within the same follow-up duration strata.

^eConverted from accelerated factor.

^fNot applicable for hip fracture due to its dichotomization.