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The cartoon depicts two distinct states of pluripotency (naïve and primed) separated by epigenetic barrier resulted from distinct epigenetic events. This ensures the identity of each states characterized by lineage specific transcription factor expression and H3K4me1 on MLL1 target promoters. Pharmacological inhibition of MLL1 erases epigenetic script of EpiSCs and cross the barrier thereby reprogrammed into developmental ground state ESCs.
