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EGF and EGFR axis. Intrarenal EGF expression is decreased due to tubular injury, and decreased urine EGF excretion is a better biomarker for CKD progression. Although EGFR activation promotes cell proliferation and regeneration, activated EGFR may induce interstitial fibrosis or hypertension. EGF, epidermal growth factor; EGFR, EGF receptor; CKD, chronic kidney disease.
