Table 2.
Mean densities (SE in parentheses) of tau-immunoreactive pathology (NFT, DN, DL, NP, AT, GI) together with abnormally enlarged neurons (EN), surviving neurons and vacuoles in gyral crests/upper side of gyri and depths of sulci of various cortical regions in 11 cases of chronic traumatic encephalopathy
| Variable | Location |
Cortical region
|
|||
|---|---|---|---|---|---|
| SFG | TP | STG | EG | ||
| NFT | Gyrus | 0.59 (0.20) | 1.73 (0.28) | 0.95 (0.30) | 1.69 (0.23) |
| Sulcus | 2.64 (0.68) | 1.69 (0.26) | 0.96 (0.20) | 1.93 (0.30) | |
| NT | Gyrus | 1.30 (0.56) | 1.96 (0.59) | 1.63 (0.72) | 3.39 (1.36) |
| Sulcus | 8.27 (1.84) | 3.01 (0.69) | 2.56 (0.59) | 6.20 (1.55) | |
| DL | Gyrus | 8.45 (2.24) | 20.88 (5.51) | 12.58 (3.92) | 22.25 (6.44) |
| Sulcus | 27.43 (5.09) | 28.47 (3.57) | 21.53 (5.84) | 50.00 (8.16) | |
| NP | Gyrus | 0 | 0.002 (0.001) | 0.01 (0.01) | 0.01 (0.01) |
| Sulcus | 0.01 (0.01) | 0.02 (0.01) | 0.05 (0.03) | 0 | |
| AT | Gyrus | 0.11 (0.04) | 0.20 (0.06) | 0.15 (0.04) | 0.21 (0.05) |
| Sulcus | 0.28 (0.08) | 0.24 (0.07) | 0.18 (0.04) | 0.21 (0.07) | |
| GI | Gyrus | 0.02 (0.01) | 0.01 (0.01) | 0.02 (0.01) | 0.01 (0.01) |
| Sulcus | 0.01 (0.01) | 0.02 (0.01) | 0.02 (0.01) | 0.01 (0.01) | |
| EN | Gyrus | 0.21 (0.04) | 0.27 (0.05) | 0.14 (0.03) | 0.41 (0.09) |
| Sulcus | 0.29 (0.07) | 0.29 (0.05) | 0.13 (0.03) | 0.28 (0.06) | |
| Neurons | Gyrus | 10.35 (1.00) | 10.33 (1.12) | 11.70 (0.81) | 8.93 (1.15) |
| Sulcus | 10.43 (1.16) | 11.66 (0.70) | 12.05 (0.79) | 10.96 (1.61) | |
| Vacuoles | Gyrus | 5.24 (0.68) | 6.88 (1.58) | 6.40 (1.06) | 4.94 (1.55) |
| Sulcus | 4.19 (1.86) | 4.61 (1.18) | 4.27 (0.64) | 3.94 (0.77) | |
Analysis of variance (ANOVA) (two-factor split plot): NFT region F = 1.89 (P > 0.05), gyrus/sulcus F = 8.44 (P < 0.01), interaction F = 6.64 (P < 0.001); NT region F = 2.28 (P > 0.05), gyrus/sulcus F = 31.03 (P < 0.001), interaction F = 7.11 (P < 0.001); DL region F = 3.30 (P < 0.05), gyrus/sulcus F = 45.62 (P < 0.001), interaction F = 4.06 (P > 0.05); AT region F = 0.22 (P > 0.05), gyrus/sulcus F = 4.61 (P < 0.05), interaction F = 1.69 (P > 0.05); GI region F = 0.45 (P > 0.05), gyrus/sulcus F = 1.02 (P > 0.05), interaction F = 0.51 (P > 0.05); EN region F = 3.85 (P < 0.05), gyrus/sulcus F = 0.10 (P > 0.05), interaction F = 2.19 (P > 0.05); neurons region F = 3.85 (P < 0.05), gyrus/sulcus F = 3.61 (P > 0.05), interaction F = 0.81 (P > 0.05); vacuoles region F = 0.37 (P > 0.05), gyrus/sulcus F = 10.59 (P < 0.01), interaction F = 0.52 (P > 0.05).
SFG, Superior frontal cortex; TP, Temporal pole; STG, Superior temporal gyrus; EC, Entorhinal cortex.