Table 1.
Baseline, Year 3 and Year 6 characteristics of the 872 WHI OS frail older women by hip-fracture incidence
| Characteristics | Fracture (n = 49) |
Non-fracture (n = 823) |
P value |
|---|---|---|---|
| Agea, yr (SD) | 73.84 (4.55) | 72.21 (4.52) | 0.015 |
| Whiteb, n (%) | 47 (95.9) | 642 (78.10) | 0.003 |
| Incomeb, n (%) | 0.467 | ||
| ≤$20000 | 14 (28.57) | 295 (36.42) | |
| $20000–$50000 | 21 (42.86) | 331 (40.86) | |
| >$50000 | 14 (28.57) | 184 (22.72) | |
| BMIa, kga/m2 (SD) | 26.28 (4.84) | 29.44 (6.34) | 0.006 |
| Heighta, cm (SD) | 160.18 (5.98) | 159.99 (6.24) | 0.84 |
| Weighta, kg (SD) | 67.33 (12.53) | 75.43 (17.02) | 0.001 |
| Smokera, n (%) | 4 (8.16) | 52 (6.42) | 0.63 |
| Previous fractureb, n (%) | 19 (44.19) | 111 (13.79) | 0.001 |
| Recurrent Falls in 12 monthb, n (%) | 16 (33.33) | 0.51 (0.84) | <0.001 |
| Total hip BMDa, g/cm (SD) | 0.72 (0.09) | 0.83 (0.14) | <0.001 |
| Number of Frailty criteria, n (%) | 0.407 | ||
| 3 criteria | 24 (48.98) | 458 (55.65) | |
| 4 criteria | 21 (42.86) | 328 (39.85) | |
| 5 criteria | 4 (8.16) | 37 (4.50) | |
| Body-composition measures | |||
| Static indexes | |||
| ALM/height2, kg/m2 (SD) | 5.38 (0.99) | 5.72 (1.12) | 0.04 |
| AFM/height2, kg/m2 (SD) | 5.61 (1.95) | 6.76 (2.34) | <0.001 |
| TLM/height2, kg/m2 (SD) | 7.56 (1.01) | 7.65 (1.00) | 0.49 |
| TFM/height2, kg/m2 (SD) | 5.02 (2.06) | 6.36 (2.46) | <0.001 |
| WBLM/height2, kg/m2 (SD) | 13.94 (1.88) | 14.43 (2.00) | 0.09 |
| WBFM, /height2, kg/m2 (SD) | 11.13 (3.71) | 13.63 (4.59) | <0.001 |
| Dynamic indexes | Fracture (n = 32)c | Non-fracture (547)c | |
| % change in weight, % (SD) | −0.95 (7.72) | 0.62 (11.93) | 0.46 |
| % change in height, % (SD) | −0.52 (1.50) | −0.65 (1.61) | 0.65 |
| % change in ALM, % (SD) | −0.43 (9.65) | 1.86 (9.98) | 0.21 |
| % change in AFM, % (SD) | −1.59 (13.02) | −1.24 (12.89) | 0.88 |
| % change in TLM, % (SD) | −0.15 (7.98) | 1.25 (6.72) | 0.25 |
| % change in TFM, % (SD) | −4.68 (21.16) | −2.71 (18.43) | 0.56 |
| % change in WBLM, % (SD) | −1.13 (6.44) | 0.31 (5.38) | 0.28 |
| % change in WBFM, % (SD) | −2.00 (15.97) | −1.09 (13.37) | 0.71 |
ALM = appendicular lean mass; AFM = appendicular fat mass; TLM = trunk lean mass; TFM = trunk fat mass; SD = standard deviation; WBLM = whole-body lean mass; WBFM = whole body fat mass
a
Year 3 measure;
b
Baseline measure;
c
Incident hip fractures after Year 6 measure