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. 2015 Dec 12;53(10):6869–6881. doi: 10.1007/s12035-015-9586-3

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© The Author(s) 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — The ‘bell-shaped’ Zn titration curve obtained in the competition-like experiments, with the enhancement (~10 μM of Zn) and inhibition (above 100 μM of Zn) of [³H]-8-OH-DPAT binding at 5-HT_1ARs. The curve was generated by fitting the data to equation 2 (a). Displacement of specific [³H]-8-OH-DPAT binding by 5-HT in the absence (black circle; K _i = 8.7 ± 0.6 nM) or presence of 10 μM (black square; K _i = 5.4 ± 0.2 nM; p < 0.05) and 500 μM (black triangle; K _i = 8.1 ± 0.6 nM) of Zn (b)