Fig. 5.

Effect of Zn and 8-OH-DPAT given alone and jointly using the doses that did not affect immobility time in the FST in rats (a) and the effect of pretreatment with WAY-100635 on Zn-induced reduction in immobility time (b). Zn and 8-OH-DPAT were administered alone or jointly 30 min before the FST (a). WAY-100635 was administered 15 min before the Zn treatment, and the FST test was performed 30 min after Zn treatment (b). The values represent the mean ± SEM (n = 5–8 rats). *p < 0.05; **p < 0.01 vs. the VEH group; ^# p < 0.05 vs. the Zn treatment group. Statistical analysis was performed using one-way ANOVA followed by Dunnett’s post hoc test