Table 2.
Association and dissociation rate constants of [3H]-8-OH-DPAT obtained in the kinetic experiments in the absence and presence of Zn
k on [M−1 min−1] | k off fast [min−1] | k off slow [min−1] | |
---|---|---|---|
Control | 3.4 ± 0.4 × 10+8 | 2.33 ± 0.31 | 0.21 ± 0.02 |
+10 μM Zn2+ | 6.4 ± 0.8 × 10+8* | 0.25 ± 0.04a | |
+500 μM Zn2+ | 3.6 ± 0.3 × 10+8 | 0.58 ± 0.07** | 0.06 ± 0.02** |
*p < 0.07; **p < 0.05
aone phase