Table 1.
Univariate and multivariate $ logistic regressions predicting impact of dengue epidemics on 6 adverse obstetrical outcomes for 107776 pregnant women residing in the Cayenne area, French Guiana. 2004–2007
| Outcomes | Pregnancy period | N confirmed dengue cases | N events (%) | Crude OR [95%CI] | Adj. OR [95%CI] | P(Wald’s test) |
|---|---|---|---|---|---|---|
|
| ||||||
| Preterm birth | First trimester | <20 | 246 (10.5) | 1 | 1 | - |
| 20–60 | 112 (10.6) | 1.00 [0.79, 1.27] | 1.17 [0.89, 1.54] | 0.268 | ||
| >60 | 926 (12.6) | 1.22 [1.05, 1.41] | 1.31 [1.06, 1.63] | 0.014* | ||
|
| ||||||
| Second trimester | <20 | 198 (11.0) | 1 | 1 | - | |
| 20–60 | 133 (12.2) | 1.12 [0.89, 1.42] | 1.12 [0.84, 1.5] | 0.423 | ||
| >60 | 953 (12.1) | 1.11 [0.95, 1.31] | 0.96 [0.71, 1.3] | 0.796 | ||
|
| ||||||
| Last 3 months | <20 | 164 (12.1) | 1 | 1 | - | |
| 20–60 | 122 (11.1) | 0.90 [0.70, 1.16] | 0.90 [0.69, 1.17] | 0.442 | ||
| >60 | 998 (12.0) | 0.99 [0.83, 1.18] | 0.95 [0.75, 1.22] | 0.702 | ||
|
| ||||||
| Postpartum hemorrhage | First trimester | <20 | 45 (1.9) | 1 | 1 | |
| 20–60 | 36 (3.4) | 1.78 [1.14, 2.78] | 2.39 [1.46, 3.93] | < 0.001* | ||
| >60 | 312 (4.2) | 2.25 [1.64, 3.08] | 3.06 [2.04, 4.59] | < 0.001* | ||
|
| ||||||
| Second trimester | <20 | 58 (3.2) | 1 | 1 | ||
| 20–60 | 37 (3.4) | 1.05 [0.69, 1.60] | 1.65 [1.01, 2.68] | 0.044* | ||
| >60 | 298 (3.8) | 1.18 [0.89, 1.57] | 0.91 [0.57, 1.46] | 0.689 | ||
|
| ||||||
| Last 3 months | <20 | 46 (3.4) | 1 | 1 | - | |
| 20–60 | 51 (4.6) | 1.38 [0.92, 2.07] | 1.47 [0.95, 2.28] | 0.086 | ||
| >60 | 296 (3.6) | 1.05 [0.76, 1.44] | 0.97 [0.65, 1.45] | 0.890 | ||
|
| ||||||
| Low birth weight | First trimester | <20 | 243 (10,4) | 1 | 1 | - |
| 20–60 | 104 (9,8) | 0.93 [0.73, 1.19] | 1.02 [0.74, 1.39] | 0.907 | ||
| >60 | 930 (12,6) | 1.24 [1.07, 1.44] | 1.19 [0.97, 1.47] | 0.099 | ||
|
| ||||||
| Second trimester | <20 | 94 (12.6) | 1 | 1 | - | |
| 20–60 | 76 (10.6) | 0.82 [0.60, 1.13] | 0.89 [0.59, 1.35] | 0.596 | ||
| >60 | 1107 (11.9) | 0.94 [0.75, 1.17] | 0.84 [0.62, 1.14] | 0.270 | ||
|
| ||||||
| Last 3 months | <20 | 170 (12,6) | 1 | 1 | - | |
| 20–60 | 116 (10,5) | 0.82 [0.64, 1.05] | 0.84 [0.6, 1.17] | 0.297 | ||
| >60 | 991 (11,9) | 0.94 [0.79, 1.12] | 0.9 [0.71, 1.14] | 0.395 | ||
|
| ||||||
| Preeclampsia | First trimester | <20 | 47 (2.0) | 1 | 1 | - |
| 20–60 | 14 (1.3) | 0.65 [0.36, 1.18] | 0.74 [0.39, 1.41] | 0.367 | ||
| >60 | 179 (2.4) | 1.21 [0.88, 1.68] | 1.22 [0.83, 1.80] | 0.304 | ||
|
| ||||||
| Second trimester | <20 | 22 (1.9) | 1 | 1 | - | |
| 20–60 | 12 (1.7) | 0.56 [0.28, 1.14] | 0.57 [0.27, 1.22] | 0.148 | ||
| >60 | 206 (2.2) | 0.75 [0.48, 1.17] | 0.79 [0.48, 1.29] | 0.349 | ||
|
| ||||||
| Last 3 months | <20 | 35 (2.6) | 1 | 1 | - | |
| 20–60 | 25 (2.3) | 0.87 [0.52, 1.47] | 1.06 [0.6, 1.86] | 0.842 | ||
| >60 | 180 (2.2) | 0.83 [0.58, 1.20] | 0.80 [0.53, 1.20] | 0.284 | ||
|
| ||||||
| Caesarean section | First trimester | <20 | 431 (18.5) | 1 | 1 | |
| 20–60 | 198 (18.6) | 0.65 [0.36, 1.18] | 0.74 [0.39, 1.41] | 0.367 | ||
| >60 | 1525 (20.7) | 1.21 [0.88, 1.68] | 1.22 [0.83, 1.80] | 0.304 | ||
|
| ||||||
| Second trimester | <20 | 159 (21.3) | 1 | 1 | ||
| 20–60 | 144 (20.1) | 0.56 [0.28, 1.14] | 0.57 [0.27, 1.22] | 0.148 | ||
| >60 | 1851 (19.9) | 0.75 [0.48, 1.17] | 0.79 [0.48, 1.29] | 0.349 | ||
|
| ||||||
| Last 3 months | <20 | 254 (18.8) | 1 | 1 | ||
| 20–60 | 211 (19,2) | 0.87 [0.52, 1.47] | 1.06 [0.60, 1.86] | 0.842 | ||
| >60 | 1689 (20.3) | 0.83 [0.58, 1.20] | 0.80 [0.53, 1.20] | 0.284 | ||
|
| ||||||
| Malformations | First trimester | <20 | 24 (1.0) | 1 | 1 | |
| 20–60 | 18 (1.6) | 1.66 [0.90, 3.07] | 1.66 [0.88, 3.15] | 0.118 | ||
| >60 | 118 (1.7) | 1.57 [1.01, 2.44] | 1.42 [0.88, 2.28] | 0.152 | ||
|
| ||||||
| Second trimester | <20 | 13 (1.7) | 1 | 1 | ||
| 20–60 | 14 (1.9) | 1.12 [0.52, 2.40] | 1.15 [0.52, 2.53] | 0.729 | ||
| >60 | 133 (1.4) | 0.82 [0.46, 1.45] | 0.89 [0.49, 1.62] | 0.701 | ||
|
| ||||||
| Last 3 months | <20 | 18 (1.3) | 1 | 1 | ||
| 20–60 | 14 (1.3) | 0.95 [0.47, 1.93] | 0.90 [0.43, 1.86] | 0.767 | ||
| >60 | 128 (1.5) | 1.16 [0.70, 1.90] | 1.03 [0.61, 1.75] | 0.900 | ||
*
P-value < 0.05
$
The adjustment variables in the multivariate models were the woman’s age, ethnic origin, gravidity, parity, twin pregnancy, having had a medical follow up, the number of ultrasound scans, and having had various pathologies during pregnancy, including chronic health conditions of the mother, as well as pregnancy specific medical conditions. Low birth weight (<2500 g) and preterm birth (gestation < 37 weeks) were also used depending the outcome under investigation.