Table 1. Comparison of radiological assessment criteria.
| RECIST 1.1 (Eisenhaueret al, 2009) | irRC (Wolchoket al, 2009) | CHOI (Choiet al, 2004, 2007) | mCHOI (Nathanet al, 2010) | |
|---|---|---|---|---|
| Method | Sum of the longest diameters (unidimensional) of index lesions | Sum of the products of the two largest perpendicular diameters (SPD) of all index lesions (5 lesions per organ, up to 10 visceral lesions and 5 cutaneous lesions) is calculated. Subsequently, on each scan, the SPD of the index lesions and of new, measurable lesions (⩾5 × 5 mm; up to 5 new lesions per organ: 5 new cutaneous lesions and 10 visceral lesions) are added to provide total tumour burden | Changes in tumour size (sum of the longest diameters) and changes in tumour density of index lesions | Changes in tumour size (sum of the longest diameters) and changes in tumour density of index lesions |
| Complete response | Disappearance of all target lesions or nodal short axis diameter <10 mm on follow-up | Disappearance of all lesions in two consecutive observations not <4 weeks apart | Disappearance of all lesions No new lesions | Disappearance of all target lesion |
| Partial response | >30% decrease in sum of longest diameter (LD) | >50% decrease in the burden of tumour compared with baseline in two observations at least 4 weeks apart | Decrease in size of >10% or a >15% decrease in tumour density (HU). No new lesions | Decrease in size of >10% and >15% decrease in tumour density (HU). No new lesions |
| Progressive disease | >20% increase in sum of LD taking as reference the smallest LD recorded and at least 5 mm increase or new lesion | Increase in tumour burden >25% relative to the minimum recorded tumour burden in two consecutive observations, at least 4 weeks apart | >10% increase in tumour size and does not meet criteria of PR by tumour density. New lesions | >10% increase in tumour size and does not meet criteria of PR by tumour density. New lesions |
| Stable disease | Neither PR nor PD | Neither of the above | Does not meet criteria of CR, PR or PD | Does not meet criteria of CR, PR or PD |
Abbreviations: CR=complete response; irRC=immune-related response criteria; mCHOI=modified CHOI; PD=progressive disease; PR=partial response; RECIST=response evaluation criteria in solid tumors.