Table 3. Multivariable Cox proportional hazards models of uric acid, individual NCCN-IPI items, and serum creatinine for the prediction of overall and PFS in patients with DLBCL (n=539).
|
Multivariable analysis OS |
Multivariable analysis PFS |
|||
|---|---|---|---|---|
| Variable | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Uric acid (per 1 log increase) | 1.54 (1.07–2.22) | 0.020 | 1.45 (1.05–2.01) | 0.025 |
| Age category | ||||
| ⩽40 years | 1 (ref.) | – | 1 (ref.) | – |
| 41–60 years | 1.97 (0.56–6.88) | 0.289 | 1.43 (0.64–3.18) | 0.385 |
| 61–75 years | 3.98 (1.24–12.74) | 0.020 | 2.10 (1.01–4.36) | 0.048 |
| >75 years | 9.31 (2.90–29.95) | <0.0001 | 3.64 (1.73–7.68) | 0.001 |
| Site | ||||
| No extranodal disease | 1 (ref.) | – | 1 (ref.) | – |
| Extranodal disease | 1.21 (0.88–1.65) | 0.242 | 1.16 (0.87–1.54) | 0.317 |
| LDH ratio | ||||
| <ULN | 1 (ref.) | – | 1 (ref.) | – |
| 1–3 × ULN | 1.22 (0.85–1.75) | 0.286 | 1.26 (0.91–1.75) | 0.157 |
| >3 × ULN | 1.87 (1.15–3.03) | 0.011 | 1.93 (1.23–3.02) | 0.004 |
| Clinical stage (Ann Arbor) | ||||
| I&II | 1 (ref.) | – | 1 (ref.) | – |
| III&IV | 1.78 (1.27–2.48) | 0.001 | 1.55 (1.15–2.09) | 0.004 |
| ECOG PS | ||||
| 0–2 | 1 (ref.) | – | 1 (ref.) | – |
| ⩾2 | 1.46 (1.00–2.12) | 0.049 | 1.40 (0.98–1.99) | 0.065 |
| Serum creatinine (per 1 mg dl−1 increase) | 1.04 (0.89–1.21) | 0.643 | 1.00 (0.85–1.17) | 0.951 |
Abbreviations: CI=confidence interval; DLBCL=diffuse large B-cell lymphoma; ECOG PS=Eastern Cooperative Oncology Group (ECOG) performance status (PS); HR=hazard ratio; LDH=lactate dehydrogenase; NCCN-IPI=National Comprehensive Cancer Network International Prognostic Index; OS=Overall survival; P=Wald-test P-value; PFS=progression-free survival. Bold indicates P<0.05.