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A model for PTP-MEG2 regulation of TrkA biosynthesis and signaling. On one hand, PTP-MEG2 dephosphorylates NSF to relieve the block of anterograde transport of post-Golgi vesicles carrying TrkA to the plasma membrane (left). On the other hand, PTP-MEG2 also acts on pTrkA at the plasma membrane and/or endosomes, leading to dephosphorylation of TrkA and down-regulation of NGF/TrkA signal transduction and neurite differentiation in neurons (right).
