FIGURE 1.
CNTNAP2 and CNTN2. A, domain structure of CNTNAP2 and CNTN2. CNTNAP2 contains a coagulation factor 5/8 type C (F58C) domain; laminin, neurexin, sex hormone binding globulin (LNS or L) domains; egf-like repeats (egf); and a fibrinogen-like (FBG) domain. CNTN2 contains Ig and fibronectin type III domains (FN). Signal peptides (SP) and trans-membrane domain (TM) are indicated. B, CNTNAP2 constructs used in this study. C, CNTN2-C1 construct used in this study. CNTN1-C1 has an analogous domain organization. To improve legibility, CNTNAP2-C1 is abbreviated to CNTNAP2, CNTN2-C1 to CNTN2, and CNTN1-C1 to CNTN1 throughout the text.